Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity
Peter A. Halim, Hanan H. Georgey, Mina Y. George, Ahmed M. El Kerdawy, Mona F. Said
Topics & Concepts
ChemistryAnalgesicTolerabilityPharmacologyCelecoxibEdemaAnti-inflammatorySelectivityCarrageenanUlcer indexStomachBiochemistryGastric mucosaAdverse effectMedicineInternal medicineCatalysisQuinazolinone synthesis and applicationsPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and biological activity