Facile 3-chloro-1H-indazole based 1,3,4-thiadiazole derivatives as novel thymidine phosphorylase and anti-diabetic inhibitors: Experimental, in-vitro and molecular modelling approaches
Yousaf Khan, Aneela Maalik, Wajid Rehman, Hina Sarfraz, Rafaqat Hussain, Shoaib Khan, Marouan Kouki, Aisha Usman, Rubina Adnan
Topics & Concepts
IndazoleThymidine phosphorylaseChemistryIC50AcarboseThymidineEnzymeSemicarbazoneIn vitroIsatinStereochemistryDocking (animal)Active siteLead compoundCombinatorial chemistryBiochemistryOrganic chemistryMedicineNursingBiochemical and Molecular ResearchCarbohydrate Chemistry and SynthesisChronic Lymphocytic Leukemia Research