Legionella pneumophila Cas2 Promotes the Expression of Small Heat Shock Protein C2 That Is Required for Thermal Tolerance and Optimal Intracellular Infection
Jackson A. Campbell, Nicholas P. Cianciotto
Abstract
is upregulated by the presence of Cas2, and HspC2 uniquely promotes both L. pneumophila extracellular survival at high temperatures and infection of amoebal and human host cells. To our knowledge, these findings also represent the first genetic proof linking Cas2 to thermotolerance, expanding the repertoire of noncanonical functions associated with CRISPR-Cas proteins.
Topics & Concepts
Legionella pneumophilaBiologyIntracellularHeat shock proteinMicrobiologyLegionnaires' diseaseLegionellaIntracellular parasiteBacteriaCell biologyBiochemistryGeneticsGeneLegionella and Acanthamoeba researchEndoplasmic Reticulum Stress and DiseaseVibrio bacteria research studies