PBAT hollow porous microfibers prepared via electrospinning and their functionalization for potential peptide release
Yufei Liu, Long Yang, Guijing Chen, Zhentao Liu, Tao Lu, Yong Yang, Jia Yu, Jia Yu, Dongdong Kang, Wei Yan, Min He, Shuhao Qin, Jie Yu, Jie Yu, Chuan Ye, Heng Luo
Abstract
Although microfiber (MF) loaded polypeptides have been widely studied in the field of medicine, load control and slow release remain significant challenges. Herein, polybutylene adipate terephthalate (PBAT) hollow porous MFs (HPMFs) were prepared by improving and regulating the groups and structures of the MFs to address these challenges. The capacity of the HPMFs for the loading of polypeptide can be improved. Measurements involving the use of X-ray photoelectron, energy-dispersive, and ultraviolet (UV) spectroscopies in conjunction with scanning electron microscopy measurements showed that the amount of polypeptide (arginylglycylaspartic acid, RGD) loaded on the HPMFs was significantly higher than that loaded on the MFs. Animal cell experiments revealed that PBAT grafted MAH has good bioactivity. By loading RGD onto HPMFs and MFs, [email protected] and [email protected] were obtained. A study on HeLa and A549 cancer cells showed that the inhibition rates of [email protected] were higher than that of [email protected] by 14.1% and 6.9%, respectively. The results obtained herein show that HPMF scaffold preparation by improving the material groups and regulating the structure of MFs can address the challenges associated with control of the load and sustained release of polypeptides and other drugs.