Quinolizidine alkaloids from the roots of <i>Sophora flavescens</i>
Jianchun Li, Zhi‐Jun Zhang, Dan Liu, Mingyan Jiang, Rong‐Tao Li, Hongmei Li
Abstract
Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 μM, while lupanine (17) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 μg/mL.
Topics & Concepts
QuinolizidineSophora flavescensMatrineSophoraNitric oxideChemistryAlkaloidTwo-dimensional nuclear magnetic resonance spectroscopyHeteronuclear single quantum coherence spectroscopyStereochemistryIC50Traditional medicineIn vitroBiochemistryChromatographyOrganic chemistryTraditional Chinese medicineMedicineAlternative medicinePathologyBioactive natural compoundsNatural product bioactivities and synthesisTraditional and Medicinal Uses of Annonaceae