Combinatorial screening SlipChip for rapid phenotypic antimicrobial susceptibility testing
Xiang Li, Xu Liu, Ziqing Yu, Yang Luo, Qixin Hu, Zhenye Xu, Jia Dai, Nannan Wu, Feng Shen
Abstract
strains were isolated from patients diagnosed with urinary tract infections (UTIs), and an individual isolate was tested using four antibiotics and eleven antibiotic combinations simultaneously with three different concentrations of each. The results from the cs-SlipChip agree with those of a VITEK 2 automated system. This cs-SlipChip provides a practical high-throughput and rapid phenotypic method for AST and can also be used to screen different chemicals and antibiotic combinations for the treatment of multiple antibiotic-resistant bacteria.
Topics & Concepts
CiprofloxacinAntibioticsAntibiotic resistanceNitrofurantoinCeftazidimeAntimicrobialMicrobiologyAmpicillinBiologyPhenotypic screeningBacteriaEscherichia coliPhenotypeGenePseudomonas aeruginosaGeneticsBacterial Identification and Susceptibility TestingAntibiotic Resistance in BacteriaUrinary Tract Infections Management