Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans
Vivaswath S. Ayyar, Dawei Song, Songmao Zheng, Thomas Carpenter, Donald Heald
Topics & Concepts
Gene knockdownGene silencingPharmacokineticsSmall interfering RNABiodistributionEndosomePharmacologyEndocytosisAsialoglycoprotein receptorChemistryRNA interferenceRNACell biologyBiologyMolecular biologyBiochemistryReceptorIn vitroGeneHepatocyteRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry