11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F. Carter, Elijah Mak, Young T. Hong, Selena Milicevic Sephton, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O’Brien
Abstract
Abstract Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission tomography (PET) imaging of 11 C-UCB-J, a ligand for presynaptic vesicle protein 2A (SV2A), a vesicle membrane protein ubiquitously expressed in synapses. Methods We performed 11 C-UCB-J PET in two DLB patients (an amyloid-negative male and an amyloid-positive female in their 70s) and 10 similarly aged healthy controls. The DLB subjects also underwent PET imaging of amyloid ( 11 C-PiB) and tau ( 18 F-AV-1451). 11 C-UCB-J binding was quantified using non-displaceable binding potential (BP ND ) determined from dynamic imaging. Changes in 11 C-UCB-J binding were correlated with MRI regional brain volume, 11 C-PiB uptake and 18 F-AV-1451 binding. Results Compared to controls, both patients had decreased 11 C-UCB-J binding, especially in parietal and occipital regions (FDR-corrected p < 0.05). There were no significant correlations across regions between 11 C-UCB-J binding and grey matter, tau ( 18 F-AV1451) or amyloid ( 11 C-PiB) in either patient. Conclusions Quantitative imaging of in vivo synaptic density in DLB is a promising approach to understanding the mechanisms of DLB, over and above changes in grey matter volume and concurrent amyloid/tau deposition.