Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice
Ji Wang, Hongsheng Chen, Hou‐Hong Li, Huajie Wang, Ruo-Si Zou, Xiao‐Jia Lu, Jie Wang, Binbin Nie, Jinfeng Wu, Shuang Li, Baoci Shan, Pengfei Wu, Li‐Hong Long, Zhuang‐Li Hu, Jianguo Chen, Fang Wang
Topics & Concepts
Synaptic pruningNeurosciencePrefrontal cortexMicrogliaSynapseChronic stressPostsynaptic potentialExcitatory postsynaptic potentialNeurotransmissionSocial defeatDendritic spinePsychologyMedicineInhibitory postsynaptic potentialInflammationHippocampal formationInternal medicineCognitionReceptorNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeuroscience and Neuropharmacology Research