Immunotherapy for pancreatic ductal adenocarcinoma
Eileen S. Carpenter, Sarah C. Nelson, Filip Bednar, Clifford Cho, Hari Nathan, Vaibhav Sahai, Marina Pasca di Magliano, Timothy L. Frankel
Abstract
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer with an urgent need for better medical therapies. Efforts have been made to investigate the efficacy of immunotherapy, particularly given the hallmarks of immune suppression and exhaustion in PDAC tumors. Here, we review the molecular components responsible for the immune-privileged state in PDAC and provide an overview of the immunotherapeutic strategies for PDAC including vaccine therapy, checkpoint blockade, myeloid-targeted therapy, and immune agonist therapy.
Topics & Concepts
MedicineImmunotherapyImmune systemPancreatic ductal adenocarcinomaPancreatic cancerImmune checkpointBlockadeAdenocarcinomaCancerOncologyTargeted therapyMyeloidPancreatic carcinomaCancer researchImmunologyInternal medicineReceptorPancreatic and Hepatic Oncology ResearchCancer Immunotherapy and BiomarkersImmune cells in cancer