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A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart

Himangshu S. Bose, Randy M. Whittal, Brendan Marshall, Maheshinie Rajapaksha, Ning Wang, Madhuchanda Bose, Elizabeth W. Perry, Zhi‐Qing Zhao, Walter L. Miller

2021Journal of Pharmacology and Experimental Therapeutics15 citationsDOIOpen Access PDF

Topics & Concepts

Aldosterone synthaseAldosteroneSteroidogenic acute regulatory proteinCholesterol side-chain cleavage enzymeInternal medicineEndocrinologyBiologyMitochondrionCell biologyMedicineBiochemistryMetabolismGeneMessenger RNARenin–angiotensin systemBlood pressureCytochrome P450Hormonal Regulation and HypertensionEicosanoids and Hypertension PharmacologyApelin-related biomedical research