Pseudomonas aeruginosa Induces Interferon-β Production to Promote Intracellular Survival
Ling Yang, Yu-Wei Zhang, Yang Liu, Ying-Zhou Xie, Dong Weng, Bao-Xue Ge, Haipeng Liu, Jin‐Fu Xu
Abstract
The link between innate immunity and intracellular Pseudomonas aeruginosa is unclear. Our studies illuminated the role of interferon-β (IFN-β) in remote intracellular PA infection. Furthermore, our experimental evidence also indicated that IL-1β is a negative regulator of IFN-β production and, in particular, P. aeruginosa infection. The inhibition of IFN-β may be used as a potential therapeutic method against pulmonary PA infection.
Topics & Concepts
IRF3IntracellularInnate immune systemInterferonPseudomonas aeruginosaBiologyTANK-binding kinase 1Intracellular parasiteStingExtracellularInterferon regulatory factorsCell biologyMicrobiologyImmune systemInterferon gammaIRF1Transcription factorSignal transductionProtein kinase BImmunologyBacteriaGeneBiochemistryMAP kinase kinase kinaseGeneticsEngineeringAerospace engineeringinterferon and immune responsesInflammasome and immune disordersImmune Response and Inflammation