Ruthenium(II) complexes as mitochondrial inhibitors of topoisomerase induced A549 cell apoptosis
Hong Tang, Xinhua Guo, Wenzhu Yu, Jie Gao, Xufeng Zhu, Zunnan Huang, Wenhui Ou, Hanfu Zhang, Lanmei Chen, Jincan Chen
Topics & Concepts
ChemistryApoptosisRutheniumMitochondrionMembrane potentialReactive oxygen speciesTopoisomeraseInner mitochondrial membraneMitochondrial DNAIntracellularCancer cellPhenanthrolineMolecular biologyCell biologyStereochemistryBiochemistryDNACancerBiologyCatalysisGeneInorganic chemistryGeneticsCancer therapeutics and mechanismsMetal complexes synthesis and propertiesSynthesis and bioactivity of alkaloids