Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women
Johanna Roche, Peter Rasmussen, Hannes Gatterer, Giulia Roveri, Rachel Turner, Gerrit van Hall, Marc Maillard, Anna Walzl, Michael Kob, Giacomo Strapazzon, Jens P. Goetze, Simon Schäfer, Tobias Kammerer, Élie Nader, Philippe Connes, Mélanie Robert, Thomas Mueller, Eric Féraille, Christoph Siebenmann
Abstract
This study is the first to investigate the mechanisms underlying plasma volume (PV) contraction in response to hypoxia in women while strictly controlling for confounders. PV contraction in women has a similar time course and magnitude as in men and is driven by the same mechanism, namely, oncotically driven redistribution rather than loss of fluid. We further report that hypoxia facilitates an increase in diuresis, that is, however, short-lived and of little relevance for PV regulation.