Inhibiting Src-mediated PARP1 tyrosine phosphorylation confers synthetic lethality to PARP1 inhibition in HCC
Caiyu Sun, Weiqiang Jing, Gaozhong Xiong, Dapeng Ma, Yueke Lin, Xiaoting Lv, Yunxue Zhao, Xiaomin Ma, Lihui Zhu, Xuecheng Shen, Min Yang, Zhenzhi Qin, Yeping Cheng, Haocheng Xuan, Tao Li, Lihui Han
Topics & Concepts
PARP1Synthetic lethalityCancer researchPoly ADP ribose polymerasePhosphorylationMedicineProto-oncogene tyrosine-protein kinase SrcPharmacologyBiologyPolymeraseDNA repairEnzymeBiochemistryDNAPARP inhibition in cancer therapyCell death mechanisms and regulationIntegrated Circuits and Semiconductor Failure Analysis