Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA <i>NEAT1</i>
Jasmine Barra, Gabriel Gaidosh, Ezra Blumenthal, Felipe Beckedorff, Mina M. Tayari, Nina Kirstein, Tobias K. Karakach, Torben Heick Jensen, Francis Impens, Kris Gevaert, Eleonora Leucci, Ramin Shiekhattar, Jean‐Christophe Marine
Abstract
isoform switching and, thereby, restrains PS assembly. Consistently, low levels of Integrator subunits correlated with poorer prognosis of cancer patients exposed to chemotherapeutics. Our study establishes that Integrator regulates PS biogenesis and a link between Integrator, cancer biology, and chemosensitivity, which may be exploited therapeutically.
Topics & Concepts
Gene isoformBiogenesisPolyadenylationRNACell biologyIntegratorBiologyChemistryComputational biologyComputer scienceGeneticsGeneBandwidth (computing)Computer networkCancer-related molecular mechanisms researchRNA Research and SplicingRNA and protein synthesis mechanisms