Asymmetric Synthesis of Axially Chiral Anilides via Organocatalytic Atroposelective <i>N</i>-Acylation
Dawei Li, Sijing Wang, Shulin Ge, Shunxi Dong, Xiaoming Feng
Abstract
-acylation reaction of aniline-derived sulfonamides has been developed with chiral isothiourea as the catalyst. This approach provides a facile and efficient route to an array of atropoisomeric sulfonyl substituted anilide products in good yields with high to excellent enantioselectivities.
Topics & Concepts
ChemistryAcylationAnilineSulfonylCatalysisCombinatorial chemistryOrganic chemistryAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySphingolipid Metabolism and Signaling