Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and <i>in vivo</i> efficacy
Karol Al Ayed, Ross D. Ballantine, Michael Hoekstra, Samantha J. Bann, Charlotte M. J. Wesseling, Alexander T. Bakker, Zheng Zhong, Yong‐Xin Li, Nora C. Brüchle, Mario van der Stelt, Stephen A. Cochrane, Nathaniel I. Martin
Abstract
Convenient solid-phase approaches are described for the synthesis of brevicidine and laterocidine. Also reported are novel analogues including a laterocidine variant with enhanced hydrolytic stability and potent in vivo antibacterial activity.
Topics & Concepts
LipopeptideIn vivoAntibioticsAntibacterial activityIn vitroPolymyxinChemistryCombinatorial chemistryBacteriaMicrobiologyBiologyBiochemistryBiotechnologyGeneticsMicrobial Natural Products and BiosynthesisAntimicrobial Peptides and ActivitiesBiochemical and Structural Characterization