Alliin from garlic as a neuroprotective agent attenuates ferroptosis <i>in vitro</i> and <i>in vivo via</i> inhibiting ALOX15
Junjun Meng, Cheng-quan Wen, Lu Yang, Xiaofan Fan, Ruili Dang, Jianfeng Chu, Pei Jiang, Wenxiu Han, Lei Feng
Abstract
. In conclusion, our study highlights ALOX15 as a critical factor in ferroptosis associated with ICH, and shows that alliin exerts neuroprotective effects by inhibiting ALOX15-dependent ferroptosis.
Topics & Concepts
AlliinAllicinIn vivoChemistryIn vitroNeuroprotectionPharmacologySulfoxideBiochemistryBiologyOrganic chemistryBiotechnologyFerroptosis and cancer prognosisCholesterol and Lipid MetabolismCircular RNAs in diseases