A Ball-Milling-Enabled Cross-Electrophile Coupling
Andrew C. Jones, William I. Nicholson, Jamie A. Leitch, Duncan L. Browne
Abstract
The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C-C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive setups, in reaction times of 2 h. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.
Topics & Concepts
ChemistryBall millElectrophileCoupling (piping)Ball (mathematics)Organic chemistryChemical engineeringMetallurgyGeometryCatalysisMathematicsEngineeringMaterials scienceCatalytic Cross-Coupling ReactionsInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and Analysis