Activation of NRF2 blocks HIV replication and apoptosis in macrophages
Dating Han, Xiangyun Lu, Wanpeng Yin, Haijing Fu, Xiaodi Zhang, Linfang Cheng, Fuming Liu, Changzhong Jin, Xuebin Tian, Yiwen Xie, Nanping Wu
Abstract
The results showed that NRF2 activation could block HIV replication in macrophages before the integration phase and inhibited the expression of apoptotic pathways in virus-exposed macrophages. The study presents an unconventional anti-viral strategy of activation antioxidant response for HIV infection blocking.
Topics & Concepts
Oxidative stressViral replicationApoptosisTranscription factorGene knockdownBiologyImmune systemActivator (genetics)VirusVirologyImmunologyCell biologyGeneBiochemistryHIV Research and TreatmentHIV/AIDS Research and InterventionsGenomics, phytochemicals, and oxidative stress