MCT1-mediated endothelial cell lactate shuttle as a target for promoting axon regeneration after spinal cord injury
Chaoran Shi, Jiaqi Xu, Yinghe Ding, Xingyi Chen, Feifei Yuan, Fengzhang Zhu, Chunyue Duan, Jianzhong Hu, Hongbin Lü, Tianding Wu, Liyuan Jiang
Abstract
In summary, the current study highlights a novel metabolic pathway for therapeutic interventions in the treatment of SCI. Additionally, our findings indicate the potential benefits of targeting lactate transport mechanisms in recovery from SCI.
Topics & Concepts
Regeneration (biology)Spinal cord injuryAxonSpinal cordNeuroscienceCell biologyMedicineChemistryBiologyAnatomyNerve injury and regenerationNeurogenesis and neuroplasticity mechanismsMesenchymal stem cell research