A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the Solubility of Poorly Soluble Drugs: Effect of Formulation Variables on Dissolution and Stability
Sandeep Sarabu, Venkata Raman Kallakunta, Arun Butreddy, Karthik Yadav Janga, Srinivas Ajjarapu, Suresh Bandari, Feng Zhang, S. Narasimha Murthy, Michael A. Repka
Topics & Concepts
DissolutionSolubilityFenofibrateBioavailabilityGranulationChemistryChromatographyDifferential scanning calorimetryChemical engineeringMaterials scienceOrganic chemistryPharmacologyThermodynamicsMedicineEngineeringPhysicsComposite materialDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesAnalytical Methods in Pharmaceuticals