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BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening

Martijn Kerkhofs, Rita La Rovere, Kirsten Welkenhuysen, Ann Janssens, Peter Vandenberghe, Muniswamy Madesh, Jan B. Parys, Geert Bultynck

2021Cell Calcium37 citationsDOIOpen Access PDF

Topics & Concepts

Mitochondrial permeability transition poreProgrammed cell deathMitochondrionCell biologyApoptosisBiologyEndoplasmic reticulumIntracellularCancer cellBcl-2 familyCellCancer researchCancerBiochemistryGeneticsCell death mechanisms and regulationATP Synthase and ATPases ResearchCancer-related Molecular Pathways
BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening | Litcius