Esterase‐Activatable Synthetic M<sup>+</sup>/Cl<sup>−</sup> Channel Induces Apoptosis and Disrupts Autophagy in Cancer Cells
Javid Ahmad Malla, Virender Kumar Sharma, Mayurika Lahiri, Pinaki Talukdar
Abstract
Abstract The formation of a supramolecular synthetic M + /Cl − channel in the membrane phospholipid bilayer has been reported upon activation of a methyl pivalate‐linked N 1 , N 3 ‐dialkyl‐2‐hydroxyisophthalamide by esterases. The channel formation induces apoptosis in cancer cells via the intrinsic pathway. Interestingly, the supramolecular channel was also shown to disrupt autophagy in cancer cells by causing alkalization of lysosomes – a feature that has been confirmed at the cellular and protein level.
Topics & Concepts
AutophagyApoptosisCancer cellChemistryLipid bilayerCell biologyMembraneBiophysicsCancerBiochemistryBiologyGeneticsMolecular Sensors and Ion DetectionSupramolecular Chemistry and ComplexesMarine Toxins and Detection Methods