Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer
Yi Gou, Meirong Chen, Shanhe Li, Jungang Deng, Jinlong Li, Guihua Fang, Feng Yang, Guojin Huang
Abstract
is the first copper complex to evoke cellular events consistent with ferroptosis in cancer cells. Finally, it significantly retarded the ASPC-1 cells' growth in a mouse xenograft model.
Topics & Concepts
Pancreatic cancerChemistryCytotoxicityApoptosisIn vivoCancer cellCisplatinProgrammed cell deathConfocal microscopyCancer researchLigand (biochemistry)MitochondrionCancerCell cultureFluorescenceCell biologyIn vitroBiochemistryChemotherapyInternal medicineReceptorBiologyMedicineGeneticsPhysicsBiotechnologyQuantum mechanicsDrug Transport and Resistance MechanismsMetal complexes synthesis and propertiesFerroptosis and cancer prognosis