Photocatalyst- and additive-free site-specific C(sp<sup>3</sup>)–H hydrazination of glycine derivatives and peptides
Wang Guang-zu, Deguang Liu, Meng-Ting Liu, Yao Fu
Abstract
A visible-light-mediated site-specific C(sp<sup>3</sup>)–H hydrazination of glycine derivatives and peptides with azo compounds was developed. The C(sp<sup>3</sup>)–N coupling reaction proceeded smoothly under visible light irradiation without catalysts or additives.
Topics & Concepts
GlycineChemistryPhotocatalysisStereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryAmino acidCatalysisBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques