Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications
Bálint Mészáros, Hugo Sámano-Sánchez, Jesús Alvarado-Valverde, Jelena Čalyševa, Elizabeth Martínez-Pérez, Renato Alves, Denis C. Shields, Manjeet Kumar, Friedrich Rippmann, Lucía B. Chemes, Toby J. Gibson
Abstract
and ACE2, suggesting that these proteins could directly recruit autophagy components. Our findings identify several molecular links and testable hypotheses that could uncover mechanisms of SARS-CoV-2 attachment, entry, and replication against which it may be possible to develop host-directed therapies that dampen viral infection and disease progression. Several of these SLiMs have now been validated to mediate the predicted peptide interactions.
Topics & Concepts
IntegrinBiologyCell biologyPhosphorylationSignal transducing adaptor proteinSignal transductionProtein subunitStructural motifSequence motifComputational biologyReceptorCellScaffold proteinT-cell receptorCell adhesionViral entryRGD motifCell signalingPlasma protein bindingCell surface receptorCytosolTyrosine phosphorylationCell membraneHEK 293 cellsPeptide sequenceMembrane proteinProtein tyrosine phosphataseEndocytosisViral replicationProtein–protein interactionSARS-CoV-2 and COVID-19 ResearchPharmacological Receptor Mechanisms and EffectsCOVID-19 Clinical Research Studies