Effective drug and shRNA delivery for synergistic treatment of triple-negative breast cancer by sequentially targeting tumor hypoxia
Xuemeng Liu, Jiajia Sun, Jia Gu, Lingyan Weng, Xueting Wang, Li Zhu, Qianqian Luo, Zhongping Chen
Topics & Concepts
Hypoxia (environmental)Triple-negative breast cancerTumor microenvironmentDrug deliveryCancer researchSmall hairpin RNATumor hypoxiaIn vivoTargeted drug deliveryMicelleDrugGenetic enhancementChemistryPharmacologyGene knockdownMedicineBreast cancerCancerBiologyApoptosisRadiation therapyInternal medicineBiochemistryGeneOxygenTumor cellsAqueous solutionOrganic chemistryBiotechnologyPhysical chemistryCancer, Hypoxia, and MetabolismNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery