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Synthesis and antiproliferative activity of 1<i>H</i>-1,2,3-triazole-4<i>H</i>-chromene-<scp>d</scp>-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and molecular docking studies

Nguyễn Đình Thành, Son Hai, Thi Huyen Le, Thi Hanh Nguyen, Minh Huyền Nguyễn, Thi Ngoc Bich Vu, Thi-Thu-Hien Pham, Ngoc Toan Vu, Thi Kim Van Hoàng, Thi Kim Giang Nguyen

2022New Journal of Chemistry10 citationsDOI

Abstract

1 H -1,2,3-Triazole-4 H -chromene- d -glucose hybrids were synthesized and screened for their anticancer activity in vitro against MCF-7, HepG2, HeLa and WI-38 cells, and several had dual inhibitions against EGFR/VEGFR-2. IFD, MM-GBSA and MD simulations were also carried out.

Topics & Concepts

ChemistryHeLaIn vitroTriazoleInhibitory postsynaptic potentialDual (grammatical number)1,2,3-TriazoleStereochemistryClick chemistryCombinatorial chemistryBiochemistryOrganic chemistryNeuroscienceLiteratureArtBiologyClick Chemistry and ApplicationsSynthesis and biological activityHER2/EGFR in Cancer Research
Synthesis and antiproliferative activity of 1<i>H</i>-1,2,3-triazole-4<i>H</i>-chromene-<scp>d</scp>-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and molecular docking studies | Litcius