Regulating the surface topography of CpG nanoadjuvants <i>via</i> coordination-driven self-assembly for enhanced tumor immunotherapy
Li Zhang, Lingpu Zhang, Yuqi Wang, Kai Jiang, Chao Gao, Pengfei Zhang, Yujie Xie, Bin Wang, Yun Zhao, Haihua Xiao, Jie Song
Abstract
) showed the strongest adjuvant properties and anti-tumor immunotherapeutic effect as the adjuvant of ovalbumin in melanoma-bearing mice. Overall, this work provides an effective strategy for designing novel adjuvants for activating the immunosuppressed TME to enable better cancer immunotherapy.
Topics & Concepts
AdjuvantImmunotherapyTumor microenvironmentCancer researchCpG siteCancer immunotherapyImmune systemCpG OligodeoxynucleotideAntigenTLR9ImmunologyChemistryBiologyDNA methylationGene expressionBiochemistryGeneNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesImmune cells in cancer