The current status in computational exploration of Pt(<scp>iv</scp>) prodrug activation by reduction
Fortuna Ponte, Stefano Scoditti, Gloria Mazzone, Emilia Sicilia
Abstract
This perspective focuses on computational studies for the reduction mechanism of octahedral Pt IV complexes to afford the active Pt II species. All the plausible pathways depending on specific axial leaving ligands and reducing agents were addressed.
Topics & Concepts
ProdrugReduction (mathematics)ChemistryMechanism (biology)Combinatorial chemistryStereochemistryBiochemistryPhysicsMathematicsQuantum mechanicsGeometryMetal complexes synthesis and propertiesMolecular Junctions and NanostructuresDNA and Nucleic Acid Chemistry