Experimental colitis-induced visceral hypersensitivity is attenuated by GABA treatment in mice
Michael S. Gold, Emanuel Loeza-Alcocer
2024American Journal of Physiology-Gastrointestinal and Liver Physiology11 citationsDOIOpen Access PDF
Abstract
GABA treatment reduces the severity of colitis and inflammation and produces inhibition of visceral hypersensitivity in colon-inflamed mice. These results raise the promising possibility that GABA treatment may be an effective therapeutic strategy for the management of symptoms associated with colitis. However, clinical studies are required to corroborate whether this mouse-model data translates to human colon.
Topics & Concepts
ColitisMedicineProinflammatory cytokineUlcerative colitisInflammatory bowel diseaseInternal medicineInflammationGastroenterologyImmune systemVisceral painTumor necrosis factor alphaPharmacologyImmunologyNociceptionReceptorDiseaseDermatology and Skin DiseasesGut microbiota and healthTryptophan and brain disorders