Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function
Dietmar Vestweber
Abstract
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is a receptor-type PTP (RPTP), predominantly expressed in vascular endothelial cells. It regulates embryonic and tumor angiogenesis and controls vascular permeability and homeostasis in inflammation. Major substrates are the tyrosine kinase receptor Tie-2 and the adhesion molecule VE-cadherin. This review describes how VE-PTP controls vascular functions by its various substrates and the therapeutic potential of VE-PTP in various pathophysiological settings.
Topics & Concepts
Protein tyrosine phosphataseAngiogenesisVascular permeabilityCell biologyReceptor tyrosine kinaseBiologyVascular endothelial growth factor BPhosphataseTyrosine kinaseReceptorTyrosineInflammationCancer researchVascular endothelial growth factorVascular endothelial growth factor ASignal transductionEndocrinologyImmunologyBiochemistryPhosphorylationVEGF receptorsProtein Tyrosine PhosphatasesAngiogenesis and VEGF in CancerGalectins and Cancer Biology