Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
Naomi Shek, Anna Maria Choy, Chim C. Lang, Bruce E. Miller, Ruth Tal‐Singer, Charlotte E. Bolton, Neil C. Thomson, James D. Chalmers, Matthew J. Bown, David E. Newby, Faisel Khan, Jeffrey T. J. Huang
Abstract
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
Topics & Concepts
ElastinDiseaseMedicineFragmentation (computing)Age groupsFeature (linguistics)AgeingAge of onsetInternal medicinePathologyBiologyDemographyEcologyLinguisticsPhilosophySociologyConnective tissue disorders researchRNA Research and SplicingProtease and Inhibitor Mechanisms