Nuclear mitochondrial DNA sequences in the rabbit genome
Bálint Biró, Zoltán Gál, Giuseppina Schiavo, Anisa Ribari, Valerio Joe Utzeri, Michael Brookman, Luca Fontanesi, Orsolya Ivett Hoffmann
Abstract
Numtogenesis is observable in the mammalian genomes resulting in the integration of mitochondrial segments into the nuclear genomes (numts). To identify numts in rabbit, we aligned mitochondrial and nuclear genomes. Alignment significance threshold was calculated and individual characteristics of numts were analysed. We found 153 numts in the nuclear genome. The GC content of numts were significantly lower than the GC content of their genomic flanking regions or the genome itself. The frequency of three mammalian-wide interspersed repeats were increased in the proximity of numts. The decreased GC content around numts strengthen the theory which supposes a link between DNA structural instability and numt integration.