Dual Catalytic Platform for Enabling sp <sup>3</sup> α C–H Arylation and Alkylation of Benzamides
Alexander W. Rand, Hongfei Yin, Liang Xu, Jessica Giacoboni, Raúl Martín‐Montero, Ciro Romano, John Montgomery, Rubén Martı́n
Abstract
A dual catalytic sp3 α C–H arylation and alkylation of benzamides with organic halides is described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and enantioselectivity pattern, offering a complementary reactivity mode to existing sp3 arylation or alkylations via transition metal catalysis or photoredox events.
Topics & Concepts
ChemoselectivityAlkylationCatalysisChemistryHalideSelectivityReactivity (psychology)Combinatorial chemistryTransition metalMedicinal chemistryOrganic chemistryAlternative medicinePathologyMedicineCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions