Comment on “The neuroinvasive potential of SARS‐CoV‐2 may play a role in the respiratory failure of COVID‐19 patients”
Fatiha Chigr, Mohamed Merzouki, Mohamed Najimi
Abstract
We have read with great care and interest the article by Li et al The authors provide interesting elements with respect to the possible entry of severe acute respiratory syndrome coronavirus 2 at the brain area and plead for an implication of the central nervous system in respiratory problems linked to coronavirus disease. Here we provide additional elements that support those observations, notably the role of brainstem structures located in the medulla oblongata in modulating respiration. We also discussed the possible pathways the virus uses to cross the brain blood barrier and reach the brainstem.
Topics & Concepts
Medulla oblongataCoronavirusBrainstemCoronaviridaeRespiratory systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyCoronavirus disease 2019 (COVID-19)VirusNeuroscienceCentral nervous systemBetacoronavirus2019-20 coronavirus outbreakMedullaMedicinePonsSevere acute respiratory syndrome coronavirusBiologyDiseasePathologyInfectious disease (medical specialty)AnatomyOutbreakLong-Term Effects of COVID-19Vagus Nerve Stimulation ResearchThermal Regulation in Medicine