Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles
Yue Song, Jifan Chen, Cong Zhang, Xin Lei, Qunying Li, Yajing Liu, Chao Zhang, Shiyan Li, Pintong Huang
Abstract
with siRNA, a lentivirus system, and a subcutaneous xenograft tumor-bearing model under the condition of US with microbubbles (MBs). We found that Piezo1 was highly expressed in PDAC cells; it was activated by US with MBs and was closely related to the apoptosis of PDAC cell lines and tumors. This study highlighted the idea of utilizing the high expression of Piezo1 in PDAC and US with MBs to provide a non-invasive strategy for the treatment of PDAC from the aspect of mechanotransduction.
Topics & Concepts
PIEZO1Mechanosensitive channelsMicrobubblesSonoporationApoptosisPancreatic cancerIn vivoMechanotransductionCancer researchCellCell cultureCell biologyIn vitroChemistryUltrasoundCancerMedicineBiologyIon channelInternal medicineReceptorBiochemistryGeneticsBiotechnologyRadiologyErythrocyte Function and PathophysiologyBlood properties and coagulationHemoglobin structure and function