Visualizing the mode of action and supramolecular assembly of teixobactin analogues in <i>Bacillus subtilis</i>
Michael A. Morris, Alexander Vallmitjana, Fabian Grein, Tanja Schneider, Melina Arts, Chelsea R. Jones, Betty T. Nguyen, Mohammad H. Hashemian, Melody Malek, Enrico Gratton, James S. Nowick
Abstract
reveals a correlation between cell death and binding of the antibiotic to cellular targets, followed by lysis of cells. Collectively, these studies provide new insights into the binding of teixobactin to Gram-positive bacteria, its supramolecular mechanism of action, and the lysis of bacteria that follows.
Topics & Concepts
Bacillus subtilisMode of actionSupramolecular chemistryChemistryLipid IIAction (physics)StereochemistryComputational biologyBiologyBiochemistryGeneticsBacteriaPhysicsEnzymeOrganic chemistryMoleculeBiosynthesisQuantum mechanicsMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesEnzyme Production and Characterization