Hyponatremia and Recurrent Febrile Seizures During Febrile Episodes: A Meta-Analysis
Yoshifumi Miyagi, Tomoyuki Sasano, Hiroyuki Kato, Kentoku Kin
Abstract
86.67%, p<0.01). In the sensitivity analysis, no significant change was observed in pooled SMD. The optimal cutoff value of serum sodium level was 134.72 mmol/L with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.61, 1.00), with sensitivity of 80.0% and specificity of 70.0%. This result indicated a significant association between hyponatremia and RFS during the same febrile episode. Decreased serum sodium levels may be involved in seizure recurrence and may play a role in FS pathogenesis.
Topics & Concepts
MedicineCochrane LibraryHyponatremiaMeta-analysisInclusion and exclusion criteriaInternal medicinePublication biasMean differenceSample size determinationConfidence intervalPediatricsAlternative medicineStatisticsPathologyMathematicsEpilepsy research and treatmentElectrolyte and hormonal disordersNeonatal and fetal brain pathology