Myeloma extracellular vesicle-derived RAGE increases inflammatory responses and myotube atrophy in multiple myeloma through activation of the TLR4/NF-κB p65 pathway
Yue Wu, Xingchen Yao, Xiangjun Shi, Zi-Yu Xu, Jie Ren, Ming Shi, Meng Li, Junpeng Liu, Xinru Du
Topics & Concepts
Rage (emotion)Muscle atrophyC2C12HMGB1InflammationTLR4MyogenesisExtracellularWestern blotChemistryMolecular biologyBiologyEndocrinologyMyocyteImmunologyCell biologySkeletal muscleBiochemistryGeneNeuroscienceInflammasome and immune disordersExtracellular vesicles in diseaseChemokine receptors and signaling