Synthesis of 3-spirooxindole 3<i>H</i>-indoles through Rh(<scp>iii</scp>)-catalyzed [4 + 1] redox-neutral spirocyclization of <i>N</i>-aryl amidines with diazo oxindoles
Qianting Zhou, Xia Song, Xinying Zhang, Xuesen Fan
Abstract
Presented herein is a novel synthesis of 3-spirooxindole 3<italic>H</italic>-indoles <italic>via</italic> the coupling and spirocyclization of <italic>N</italic>-aryl amidines with diazo oxindoles.
Topics & Concepts
DiazoChemistryArylCatalysisCombinatorial chemistryRedoxStereochemistryMedicinal chemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions