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Ir(<scp>iii</scp>)-Catalyzed direct C–H functionalization of <i>N</i>-phenylacetamide with α-diazo quinones: a novel strategy for producing 2-hydroxy-2′-amino-1,2′-biaryl scaffolds

Xingjun Li, Jiang Wang, Xiong Xie, Wenhao Dai, Xu Han, Kaixian Chen, Hong Liu

2020Chemical Communications24 citationsDOI

Abstract

α-Diazo quinones were applied in an Ir(iii)-catalyzed direct C-H functionalization assisted by N-phenylacetamide for the construction of highly functionalized 2-hydroxy-2'-amino-1,1'-biaryl scaffolds in good to excellent yields. This strategy features operational simplicity, atom- and step-economy and high efficiency.

Topics & Concepts

Surface modificationChemistryCatalysisDiazoCombinatorial chemistryStereochemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions
Ir(<scp>iii</scp>)-Catalyzed direct C–H functionalization of <i>N</i>-phenylacetamide with α-diazo quinones: a novel strategy for producing 2-hydroxy-2′-amino-1,2′-biaryl scaffolds | Litcius