A triple-stimulus responsive melanin-based nanoplatform with an aggregation-induced emission-active photosensitiser for imaging-guided targeted synergistic phototherapy/hypoxia-activated chemotherapy
Jie Yu, Xiaoli Zhang, Zhichao Pei, Qi Shuai
Abstract
= 37%), desired cytocompatibility, and excellent synergistic therapeutic efficacy. The proposed nanoplatform not only extends the application scope of melanin materials with AIE-active PSs, but also offers useful insights into developing multistimulus as well as multimodal synergistic tumor treatment.
Topics & Concepts
ProdrugHypoxia (environmental)PhotosensitizerMelaninChemotherapyCancer researchChemistryPharmacologyMaterials scienceMedicineBiochemistryOxygenPhotochemistryInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced Nanomaterials in Catalysis