Endogenous Conjugation of Biomimetic Dinitrosyl Iron Complex with Protein Vehicles for Oral Delivery of Nitric Oxide to Brain and Activation of Hippocampal Neurogenesis
Cheng-Ru Wu, Yi-Da Huang, Yong-Huei Hong, Ya-Hsin Liu, Manmath Narwane, Yu‐Hsiang Chang, Trinh Kieu Dinh, Hsin-Tzu Hsieh, Yi-Jen Hseuh, Ping‐Ching Wu, Chih‐Wen Pao, Ting‐Shan Chan, I‐Jui Hsu, Yunching Chen, Hung‐Chi Chen, Ting‐Yu Chin, Tsai‐Te Lu
Abstract
and endogenous protein vehicles for an oral delivery of therapeutic NO to the brain against chronic neuropathy.
Topics & Concepts
Paracellular transportNitric oxideChemistryEndogenyBlood–brain barrierPharmacologyBiophysicsBiochemistryMedicineInternal medicineBiologyCentral nervous systemPermeability (electromagnetism)MembraneOrganic chemistryNitric Oxide and Endothelin EffectsAmino Acid Enzymes and MetabolismBarrier Structure and Function Studies