Discovery of potent small molecule PROTACs targeting mutant EGFR
Hongyi Zhao, Xueyan Yang, Hao Lei, Xiao-Xiao Xi, Shemin Lu, Junjie Zhang, Minhang Xin, San‐Qi Zhang
Topics & Concepts
T790MEpidermal growth factor receptorChemistryEGFR inhibitorsTyrosine kinaseAutophagySmall moleculeApoptosisCancer researchCell cycle checkpointCell growthCell cultureSignal transductionCell cyclePharmacologyGefitinibReceptorBiochemistryBiologyGeneticsProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments