Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease
A. Nasri, Florent Foisset, Engi Ahmed, Zakaria Mohamed Lahmar, Isabelle Vachier, Christian Jørgensen, Saïd Assou, Arnaud Bourdin, John De Vos
Abstract
Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.
Topics & Concepts
Mesenchymal stem cellLungMedicinePathologyCrosstalkEpitheliumObstructive lung diseaseRegeneration (biology)Pulmonary diseaseBiologyImmunologyCell biologyInternal medicineOpticsPhysicsNeonatal Respiratory Health ResearchCongenital Diaphragmatic Hernia StudiesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis