Unsymmetrical Disulfides Synthesis <i>via</i> Cs<sub>2</sub>CO<sub>3</sub>‐Catalyzed Three‐Component Reaction in Water
Dungai Wang, Yuanji Gao, Yunli Tong, Mingteng Xiong, Xiao Liang, Heping Zhu, Yuanjiang Pan
Abstract
Abstract An unsymmetrical disulfides synthesis by Cs 2 CO 3 ‐catalyzed three‐component coupling reaction of thioacetate, sodium thiosulfate, and benzyl halide in water is described. The safe, stable, and non‐toxic Na 2 S 2 O 3 was invoked as the sulfur‐source, successfully avoiding the odor generation in the process of S−S bond formation. A wide range of substrate suitability and appropriate functional group tolerance were observed for the transformation. Notably, the approach reported here was compatible with various biomolecules including glucose, coumarin, and quinolinone. magnified image
Topics & Concepts
ChemistryCatalysisSulfurSubstrate (aquarium)HalideFunctional groupCombinatorial chemistrySodium thiosulfateBiomoleculeCoupling reactionComponent (thermodynamics)Organic chemistryBiochemistryPolymerOceanographyPhysicsGeologyThermodynamicsSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Reactivity of Sulfur-Containing Compounds