Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models
Aurélie de Rus Jacquet, A. Ambaw, Mitali A. Tambe, Sin Ying, Michael Timmers, Mary H. Grace, Qingli Wu, James E. Simon, George P. McCabe, Mary Ann Lila, Riyi Shi, Jean‐Christophe Rochet
Abstract
a mechanism involving inhibition of the ubiquitin-proteasome system, and they alleviated deficits in mitochondrial respiration. Furthermore, an isoflavone-enriched soy extract reduced motor dysfunction exhibited by rats lesioned with the PD-related neurotoxin 6-OHDA. These findings suggest that plant-derived isoflavones could serve as dietary supplements to delay PD onset in at-risk individuals and mitigate neurodegeneration in the brains of patients.
Topics & Concepts
IsoflavonesNeuroprotectionSOY ISOFLAVONESParkinson's diseaseRed CloverDiseaseMedicinePharmacologyBiologyAgronomyInternal medicinePhytoestrogen effects and researchBiochemical effects in animalsCoenzyme Q10 studies and effects